Lifelong Reduction of LDL-Cholesterol Related to a Common Variant in the LDL-Receptor Gene Decreases the Risk of Coronary Artery Disease—A Mendelian Randomisation Study
- Linsel-Nitschke Patrick
- Götz Anika
- Erdmann Jeanette
- Braenne Ingrid
- Braund Peter
- Hengstenberg Christian
- Stark Klaus
- Fischer Marcus
- Schreiber Stefan
- El Mokhtari Nour Eddine
- Schaefer Arne
- Schrezenmeier Jürgen
- Rubin Diana
- Hinney Anke
- Reinehr Thomas
- Roth Christian
- Ortlepp Jan
- Hanrath Peter
- Hall Alistair S.
- Mangino Massimo
- Lieb Wolfgang
- Lamina Claudia
- Heid Iris M.
- Doering Angela
- Gieger Christian
- Peters Annette
- Meitinger Thomas
- Wichmann H.-Erich
- König Inke R.
- Ziegler Andreas
- Kronenberg Florian
- Samani Nilesh J.
- Schunkert Heribert
DOIAbstract
gene regarding the variability of cholesterol levels and risk of CAD. gene in three European samples comprising 6 642 adults and 533 children. Association of this SNP with CAD was examined in six case-control studies involving more than 15 000 individuals. gene locus, change in LDL-C and risk of CAD. gene locus affects LDL-C levels and, thereby, the risk for CAD
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