Pituitary Adenylate Cyclase-Activating Polypeptide Ameliorates Experimental Acute Ileitis and Extra-Intestinal Sequelae
- Heimesaat Markus M.
- Dunay Ildiko R.
- Schulze Silvia
- Fischer André
- Grundmann Ursula
- Alutis Marie
- Kühl Anja A.
- Tamas Andrea
- Toth Gabor
- Dunay Miklos P.
- Göbel Ulf B.
- Reglodi Dora
- Bereswill Stefan
DOIAbstract
The neuropeptide Pituitary adenylate cyclase-activating polypeptide (PACAP) plays pivotal roles in immunity and inflammation. So far, potential immune-modulatory properties of PACAP have not been investigated in experimental ileitis. infected mice in a time-of-treatment dependent manner.Synthetic PACAP ameliorates acute small intestinal inflammation and extra-intestinal sequelae by down-regulating Th1-type immunopathology, reducing oxidative stress and up-regulating anti-inflammatory cytokine responses. These findings provide novel potential treatment options of inflammatory bowel diseases
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