Restricted Expression of Epstein-Barr Virus Latent Genes in Murine B Cells Derived from Embryonic Stem Cells

. Because EBV infects only primate cells, it has not been possible to establish a model of infection in immunocompetent rodents. Such a model would be most desirable in order to study EBV's pathogenesis and latency in a suitable and amenable host. genes required for B-cell transformation.Our findings indicate that fundamental differences in gene regulation between mouse and man might block the route towards a tractable murine model for EBV