Variability of NT-proBNP and Its Relationship with Inflammatory Status in Patients with Stable Essential Hypertension: A 2-Year Follow-Up Study
- Roselló-Lletí Esther
- Calabuig Jose R.
- Morillas Pedro
- Cortés Raquel
- Martínez-Dolz Luis
- Almenar Luis
- González-Juanatey Jose R.
- Lauwers Catheline
- Salvador Antonio
- Portolés Manuel
- Bertomeu Vicente
- Rivera Miguel
DOIAbstract
The variability of NT-proBNP levels has been studied in heart failure, yet no data exist on these changes over time in hypertensive patients. Furthermore, studies on the relationship between natriuretic peptides and inflammatory status are limited., respectively, in the hypertrophic group. A more elevated coefficient of correlation was obtained in the hypertrophic group than in patients without hypertrophy: basal versus stage I (r = 0.79, p<0.0001 and r = 0.59, p<0.0001) and stage I versus stage II (r = 0.86, p<0.0001 and r = 0.56, p<0.0001). Finally, levels of NT-proBNP significantly correlated with sTNF-R1 (p<0.0001) and IL-6 (p<0.01) during follow-up. A multivariate linear regression analysis showed that sTNF-R1 is an independent factor ...
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