Genome-Wide Analyses of Gene Expression during Mouse Endochondral Ossification

gene expression profiles during these processes are essential to obtain a complete understanding of the regulatory mechanisms involved. microdissected tibiae screen; however, the micromass system was unable to accurately distinguish gene expression differences in the hypertrophic and mineralized zones of the tibia.These studies allow us to better understand gene expression patterns in the growth plate and endochondral bones and provide an important technical resource for comparison of gene expression in diseased or experimentally-manipulated cartilages. Ultimately, this work will help to define the genomic context in which genes are expressed in long bones and to understand physiological and pathological ossification