A Novel Multivariate Index for Pancreatic Cancer Detection Based On the Plasma Free Amino Acid Profile
- Fukutake Nobuyasu
- Ueno Makoto
- Hiraoka Nobuyoshi
- Shimada Kazuaki
- Shiraishi Koichi
- Saruki Nobuhiro
- Ito Toshifumi
- Yamakado Minoru
- Ono Nobukazu
- Imaizumi Akira
- Kikuchi Shinya
- Yamamoto Hiroshi
- Katayama Kazuhiro
DOIAbstract
The incidence of pancreatic cancer (PC) continues to increase in the world, while most patients are diagnosed with advanced stages and survive <12 months. This poor prognosis is attributable to difficulty of early detection. Here we developed and evaluated a multivariate index composed of plasma free amino acids (PFAAs) for early detection of PC.We conducted a cross-sectional study in multi-institutions in Japan. Fasting plasma samples from PC patients (n = 360), chronic pancreatitis (CP) patients (n = 28), and healthy control (HC) subjects (n = 8372) without apparent cancers who were undergoing comprehensive medical examinations were collected. Concentrations of 19 PFAAs were measured by liquid chromatography–mass spectrometry. We generate...
Add to ORKG