Study of Early Elevated Gas6 Plasma Level as a Predictor of Mortality in a Prospective Cohort of Patients with Sepsis
- Stalder Grégoire
- Que Yok Ai
- Calzavarini Sara
- Burnier Laurent
- Kosinski Christophe
- Ballabeni Pierluigi
- Roger Thierry
- Calandra Thierry
- Duchosal Michel A.
- Liaudet Lucas
- Eggimann Philippe
- Angelillo-Scherrer Anne
DOIAbstract
Growth arrest-specific gene 6 (Gas6), a vitamin K-dependent protein interacting with anionic phospholipids and TAM tyrosine kinase receptors, is elevated in plasma of septic patients. Previous studies did not find different levels between survivors and non-survivors at admission because either they included a low number of patients (<50) or a low number of non-survivors (5%).To determine, in a larger cohort of septic patients comprising an expected number of non-survivors, the performance of the plasma level of Gas6 and its soluble receptor Axl (sAxl) within 24 hours of admission to predict in-ICU mortality.Septic adults with or without shock.Gas6 and sAxl were prospectively measured by ELISA at day 0, 3, 7, and then weekly until discharge ...
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