Gene Expression Correlates to Leiomyoma Volume Regression in Response to Mifepristone Treatment
- Engman Mikael
- Varghese Suby
- Lagerstedt Robinson Kristina
- Malmgren Helena
- Hammarsjö Anna
- Byström Birgitta
- L Lalitkumar Parameswaran Grace
- Gemzell-Danielsson Kristina
DOIAbstract
gene in leiomyoma biopsies was found in 50% of the mifepristone treated cases, with lower presence of the GSTM1 protein. The findings support a significant role for GSTM1 in leiomyoma volume reduction induced by mifepristone and explain the observed individual variation in this response. Furthermore the finding could be useful to further explore GSTM1 as a biomarker for tailoring medical treatment of uterine leiomyomas for optimizing the response to treatment
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