Effect of Diabetes on Survival after Resection of Pancreatic Adenocarcinoma. A Prospective, Observational Study

Balzano Gianpaolo
Dugnani Erica
Gandolfi Alessandra
Scavini Marina
Pasquale Valentina
Aleotti Francesca
Liberati Daniela
Di Terlizzi Gaetano
Petrella Giovanna
Reni Michele
Doglioni Claudio
Bosi Emanuele
Falconi Massimo
Piemonti Lorenzo

Open link

Publication date

November 2016

DOI

10.1371/journal.pone.0166008

Publisher

Public Library of Science

Abstract

To investigate the effect of diabetes mellitus (DM) on disease-free and overall post-resection survival of patients with pancreatic ductal adenocarcinoma (PDAC)Prospective observational study on patients admitted for pancreatic disease from January 2008 to October 2012. DM was classified as recent-onset (<48 months before PDAC diagnosis), longstanding (≥48 months before PDAC) or new onset (after surgery).Of 296 patients, 140 had a diagnosis of DM prior to surgery (26 longstanding, 99 recent-onset, 15 with unknown duration). Median follow-up time was 5.4 ± 0.22 years. Patients with recent onset DM had poorer postoperative survival than patients without DM: disease-free survival and overall survival were 1.14±0.13 years and 1.52±0.12 years in...