Infections on Clinical Malaria Risk

infections and the risk of subsequent clinical malaria. gene. Malaria morbidity and anaemia was monitored during 12 months follow-up.Monthly IPT with AS+AQ resulted in a marked reduction in number of concurrent clones and only children parasite negative just after the intervention period developed clinical malaria during follow-up. In the placebo group, children without parasites as well as those infected with ≥2 clones had a reduced risk of subsequent malaria. The bimonthly SP or AS+AQ groups had similar number of clones as placebo after intervention; however, diversity and parasite negativity did not predict the risk of malaria. An interaction effect showed that multiclonal infections were only associated with protection in children without intermittent treatment. infections is important for the maintenance of protective malaria immunity in high transmission settings