Transcriptome analysis of primary monocytes shows global down-regulation of genetic networks in HIV viremic patients versus long-term non-progressors
- Wu, Jing Qin
- Ruth Sassé, Tara
- Wolkenstein, Georg
- Conceicao, Viviane
- Miranda Saksena, Monica
- Soedjono, Maly
- Perera, Suneth S.
- Wang, Bin
- Dwyer, Dominic E.
- Saksena, Nitin K.
DOIAbstract
AbstractDespite significant contributions of monocytes to HIV persistence, the genomic basis of HIV-infection of monocytes and its association with plasma viremia remain elusive. To understand HIV interactions with monocytes during disease progression, monocytic transcriptomes from long-term non-progressors (LTNP), HIV+ patients with viral load <1000, with viral load>1000, and seronegative controls were analyzed using Illumina microarray. Differentially expressed genes were identified (fold change >2; adjusted p<0.05) and GSEA between HIV+ groups demonstrated that the down-regulation of the pathways including Toll-like receptor (TLR) signaling, cytokine–cytokine receptor interaction, cell cycle and apoptosis was significantly associated wit...
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