Promoter Methylation and HNSCC: A Meta-Analysis of 21 Published Studies

promoter between cancer and the corresponding control group. Therefore, we conducted a meta-analysis to better identify the association. promoter methylation and HNSCC. promoter methylation in the cancer group were significantly higher than those in the control group (cancer group: median: 46.67%, range = 7.84%-95.12%; control group: median: 18.37%, range = 0–83.33%; respectively). The pooled odds ratio was 3.37 (95%CI = 2.32–4.90) in the cancer group versus the corresponding control group under the random-effects model. promoter was found to be significantly associated with HNSCC