F-FDG Uptake Heterogeneity Indices with Perfusion CT Derived Parameters in Colorectal Cancer
- Tixier Florent
- Groves Ashley M.
- Goh Vicky
- Hatt Mathieu
- Ingrand Pierre
- Le Rest Catherine Cheze
- Visvikis Dimitris
DOIAbstract
F-FDG PET/DCE-CT to assess the metabolic-flow phenotype. Both CT blood flow parametric maps and PET images were analyzed. Correlations between PET heterogeneity and perfusion CT were assessed by Spearman's rank correlation analysis.F-FDG PET metabolically active tumor volume as well as with uptake heterogeneity for patients with stage III/IV tumors (|ρ|:0.66 to 0.78; p-value<0.02).F-FDG PET intra-tumor heterogeneity may be associated with physiological processes such as tumor vascularization
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