SummarySomatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) with the introduction of Oct4, Sox2, Klf4, and c-Myc. Among these four factors, Oct4 is critical in inducing pluripotency because no transcription factor can substitute for Oct4, whereas Sox2, Klf4, and c-Myc can be replaced by other factors. Here we show that the orphan nuclear receptor Nr5a2 (also known as Lrh-1) can replace Oct4 in the derivation of iPSCs from mouse somatic cells, and it can also enhance reprogramming efficiency. Sumoylation mutants of Nr5a2 with enhanced transcriptional activity can further increase reprogramming efficiency. Genome-wide location analysis reveals that Nr5a2 shares many common gene targets with Sox2 and Klf4, which suggests...
SummaryIt has been suggested that the transcription factor Nanog is essential for the establishment ...
International audienceSince the initial discovery that OCT4, SOX2, KLF4, and c-MYC overexpression su...
Significant breakthroughs have been recently achieved in reprogramming somatic cells to a pluripoten...
SummarySomatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) with the introduc...
Nuclear receptor subfamily 5 group A member 2 (Nr5a2), also known as Liver Receptor Homolog -1 or LR...
Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) by expressing four trans...
SummaryThe four transcription factors Oct4, Sox2, Klf4, and c-Myc can induce pluripotency in mouse a...
The four transcription factors Oct4, Sox2, Klf4, and c-Myc can induce pluripotency in mouse and huma...
Reprogramming of somatic cells is a valuable tool to understand the mechanisms of regaining pluripot...
Oct4 is widely considered the most important among the four Yamanaka reprogramming factors. Here, we...
SummaryDifferentiated cells can be reprogrammed into induced pluripotent stem cells (iPSCs) after ov...
The generation of induced pluripotent stem cells (iPSCs) from differentiated cells following forced ...
SummarySomatic cells can be induced into pluripotent stem cells (iPSCs) with a combination of four t...
SummaryThe generation of induced pluripotent stem cells (iPSCs) from differentiated cells following ...
Differentiated cells can be reprogrammed into induced pluripotent stem cells (iPSCs) after overexpre...
SummaryIt has been suggested that the transcription factor Nanog is essential for the establishment ...
International audienceSince the initial discovery that OCT4, SOX2, KLF4, and c-MYC overexpression su...
Significant breakthroughs have been recently achieved in reprogramming somatic cells to a pluripoten...
SummarySomatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) with the introduc...
Nuclear receptor subfamily 5 group A member 2 (Nr5a2), also known as Liver Receptor Homolog -1 or LR...
Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) by expressing four trans...
SummaryThe four transcription factors Oct4, Sox2, Klf4, and c-Myc can induce pluripotency in mouse a...
The four transcription factors Oct4, Sox2, Klf4, and c-Myc can induce pluripotency in mouse and huma...
Reprogramming of somatic cells is a valuable tool to understand the mechanisms of regaining pluripot...
Oct4 is widely considered the most important among the four Yamanaka reprogramming factors. Here, we...
SummaryDifferentiated cells can be reprogrammed into induced pluripotent stem cells (iPSCs) after ov...
The generation of induced pluripotent stem cells (iPSCs) from differentiated cells following forced ...
SummarySomatic cells can be induced into pluripotent stem cells (iPSCs) with a combination of four t...
SummaryThe generation of induced pluripotent stem cells (iPSCs) from differentiated cells following ...
Differentiated cells can be reprogrammed into induced pluripotent stem cells (iPSCs) after overexpre...
SummaryIt has been suggested that the transcription factor Nanog is essential for the establishment ...
International audienceSince the initial discovery that OCT4, SOX2, KLF4, and c-MYC overexpression su...
Significant breakthroughs have been recently achieved in reprogramming somatic cells to a pluripoten...