Coronary Microvascular Dysfunction, Microvascular Angina, and Treatment Strategies
- Marinescu, Mark A.
- Löffler, Adrián I.
- Ouellette, Michelle
- Smith, Lavone
- Kramer, Christopher M.
- Bourque, Jamieson M.
DOIAbstract
AbstractAngina without coronary artery disease (CAD) has substantial morbidity and is present in 10% to 30% of patients undergoing angiography. Coronary microvascular dysfunction (CMD) is present in 50% to 65% of these patients. The optimal treatment of this cohort is undefined. We performed a systematic review to evaluate treatment strategies for objectively-defined CMD in the absence of CAD. We included studies assessing therapy in human subjects with angina and coronary flow reserve or myocardial perfusion reserve <2.5 by positron emission tomography, cardiac magnetic resonance imaging, dilution methods, or intracoronary Doppler in the absence of coronary artery stenosis ≥50% or structural heart disease. Only 8 papers met the strict incl...
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