-AR/cAMP/PKA and p38 MAPK Pathways

Du Yunhui
Yan Li
Wang Jin
Zhan Wenzhang
Song Kai
Han Xue
Li Xiao
Cao Jimin
Liu Huirong

Open link

Publication date

December 2012

DOI

10.1371/journal.pone.0052911

Publisher

Public Library of Science

Abstract

-AA isolated from the sera of dilated cardiomyopathy (DCM) patients caused the proliferation of T cells and the secretion of cytokines.-AA on T lymphocyte proliferation was examined by CCK-8 kits and CFSE assay. Western blotting was used to analyze the expressions of phospho-VASP and phospho-p38 MAPK.-AA also inhibited the secretion of interferon-γ (IFN-γ) while promoting an increase in interleukin-4 (IL-4) levels.-AR/cAMP/PKA and p38 MAPK pathways