Early Nutrition and Weight Gain in Preterm Newborns and the Risk of Retinopathy of Prematurity
- VanderVeen Deborah K.
- Martin Camilia R.
- Mehendale Reshma
- Allred Elizabeth N.
- Dammann Olaf
- Leviton Alan
DOIAbstract
To identify nutritional and weight gain limitations associated with retinopathy of prematurity (ROP) severity among very preterm newborns.1180 infants <28 weeks GA at birth with ROP examination results were grouped and analyzed by quartile of weekly total calorie, carbohydrate, protein, and lipid intake, as well as growth velocity between postnatal days 7 and 28 (adjusted for GA and birth weight Z-score). ROP was categorized by development of no, mild (<prethreshold), type 2, or type 1 ROP, as well as markers of ROP severity including stage 3 ROP, zone 1 disease, and plus disease. Associations between nutritional intake and ROP severity were compared.Greater risk for Type 1 ROP (risk/95% confidence intervals) was found for infants with lowe...
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