Transglutaminase 2, a Novel Regulator of Eicosanoid Production in Asthma Revealed by Genome-Wide Expression Profiling of Distinct Asthma Phenotypes
- Hallstrand Teal S.
- Wurfel Mark M.
- Lai Ying
- Ni Zhanglin
- Gelb Michael H.
- Altemeier William A.
- Beyer Richard P.
- Aitken Moira L.
- Henderson William R.
DOIAbstract
A frequent manifestation of asthma, exercise-induced bronchoconstriction (EIB), occurs in 30–50% of asthmatics and is characterized by increased release of inflammatory eicosanoids. The objective of this study was to identify genes differentially expressed in EIB and to understand the function of these genes in the biology of asthma.-X), an enzyme recently implicated in asthma pathogenesis. serves as the first rate-limiting step leading to eicosanoid formation, these results suggest that TGM2 may be a key initiator of the airway inflammatory cascade in asthma
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