Induction of Cell Stress in Neurons from Transgenic Mice Expressing Yellow Fluorescent Protein: Implications for Neurodegeneration Research

studies of neurodegeneration. However, these mice are often used under the assumption that the fluorescent proteins present are biologically inert.. The presence of YFP in neurons also subtly altered neuronal morphology and modified the time-course of dying-back neurodegeneration in experimental axonopathy, but not in Wallerian degeneration triggered by nerve injury., and has diverse and unpredictable effects on neurodegeneration pathways