The HPA-1 alloimmune system carried by the platelet integrin αIIbβ3 is the primary cause of alloimmune thrombocytopenia in Caucasians and the HPA-1b allele might be a risk factor for thrombosis. HPA-1a and -1b alleles are defined by a leucine and a proline, respectively, at position 33 in the β3 subunit. Although the structure of αIIbβ3 is available, little is known about structural effects of the L33P substitution and its consequences on immune response and integrin functions. mutagenesis. We then performed molecular dynamics simulations. Analyses focused on the PSI, I-EGF-1, and I-EGF-2 domains and confirmed higher exposure of residue 33 in the L33 β3 form. These analyses also showed major structural flexibility of all three domains in bo...
BACKGROUND: Studies on the inherited bleeding disorder, Glanzmann thrombasthenia (GT), have helped d...
Previously it has been shown that sequences containing both Trp25 and Leu33 are the most effective a...
Maternal alloantibodies against the human platelet Ag (HPA)-1a allotype of the platelet beta(3) inte...
The HPA-1 alloimmune system carried by the platelet integrin αIIbβ3 is the primary cause of alloimmu...
Background: The HPA-1 alloimmune system carried by the platelet integrin aIIbb3 is the primary cause...
Integrins are heterodimeric cell-adhesion receptors comprising α and β subunits. The human platelet ...
peer reviewedA single nucleotide polymorphism (SNP) at position 196 in the beta 3 integrin causes a ...
The human platelet alloantigen 1 system (HPA-1) is deter-mined by a polymorphism at position 33 in t...
BACKGROUND - The single-nucleotide polymorphism (SNP) rs5918 in the ITGB3 gene defines the human...
<div><p>Mutations in <i>ITGA2B</i> and <i>ITGB3</i> cause Glanzmann thrombasthenia, an inherited ble...
<p><strong>Molecular Dynamics Protocol with Gromacs 4.0.7</strong> This protocol had been used in th...
International audienceIntegrin αIIbβ3, a glycoprotein complex expressed at the platelet surface, is ...
International audienceBACKGROUND:Studies on the inherited bleeding disorder, Glanzmann thrombastheni...
Abstract Background Platelet adhesion and subsequent thrombus formation on a subendothelial matrix a...
<p><strong>Structure model of the beta3 subunit of integrin alphaIIb/beta3</strong>.Building process...
BACKGROUND: Studies on the inherited bleeding disorder, Glanzmann thrombasthenia (GT), have helped d...
Previously it has been shown that sequences containing both Trp25 and Leu33 are the most effective a...
Maternal alloantibodies against the human platelet Ag (HPA)-1a allotype of the platelet beta(3) inte...
The HPA-1 alloimmune system carried by the platelet integrin αIIbβ3 is the primary cause of alloimmu...
Background: The HPA-1 alloimmune system carried by the platelet integrin aIIbb3 is the primary cause...
Integrins are heterodimeric cell-adhesion receptors comprising α and β subunits. The human platelet ...
peer reviewedA single nucleotide polymorphism (SNP) at position 196 in the beta 3 integrin causes a ...
The human platelet alloantigen 1 system (HPA-1) is deter-mined by a polymorphism at position 33 in t...
BACKGROUND - The single-nucleotide polymorphism (SNP) rs5918 in the ITGB3 gene defines the human...
<div><p>Mutations in <i>ITGA2B</i> and <i>ITGB3</i> cause Glanzmann thrombasthenia, an inherited ble...
<p><strong>Molecular Dynamics Protocol with Gromacs 4.0.7</strong> This protocol had been used in th...
International audienceIntegrin αIIbβ3, a glycoprotein complex expressed at the platelet surface, is ...
International audienceBACKGROUND:Studies on the inherited bleeding disorder, Glanzmann thrombastheni...
Abstract Background Platelet adhesion and subsequent thrombus formation on a subendothelial matrix a...
<p><strong>Structure model of the beta3 subunit of integrin alphaIIb/beta3</strong>.Building process...
BACKGROUND: Studies on the inherited bleeding disorder, Glanzmann thrombasthenia (GT), have helped d...
Previously it has been shown that sequences containing both Trp25 and Leu33 are the most effective a...
Maternal alloantibodies against the human platelet Ag (HPA)-1a allotype of the platelet beta(3) inte...