Gender Differences in Survival among Adult Patients Starting Antiretroviral Therapy in South Africa: A Multicentre Cohort Study
- Cornell Morna
- Schomaker Michael
- Garone Daniela Belen
- Giddy Janet
- Hoffmann Christopher J.
- Lessells Richard
- Maskew Mhairi
- Prozesky Hans
- Wood Robin
- Johnson Leigh F.
- Egger Matthias
- Boulle Andrew
- Myer Landon
DOIAbstract
Increased mortality among men on antiretroviral therapy (ART) has been documented but remains poorly understood. We examined the magnitude of and risk factors for gender differences in mortality on ART.<0.001) and adjusted analyses (adjusted hazard ratio [AHR] 1.31, 95% CI 1.22–1.41). After 36 months on ART, men were more likely than women to be truly LTF (AHR 1.20, 95% CI 1.12–1.28) but not to die after LTF (AHR 1.04, 95% CI 0.86–1.25). Findings were consistent across all eight programmes. Virologic suppression was similar by gender; women had slightly better immunologic responses than men. Notably, the observed gender differences in mortality on ART were smaller than gender differences in age-standardised death rates in the HIV-negative S...
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