Ribonucleotide Reductase Large Subunit M1 Predicts Poor Survival Due to Modulation of Proliferative and Invasive Ability of Gastric Cancer
- Wang Qinchuan
- Liu Xiyong
- Zhou Jichun
- Huang Yasheng
- Zhang Shengjie
- Shen Jianguo
- Loera Sofia
- Yuan Xiaoming
- Chen Wenjun
- Jin Mei
- Shibata Stephen
- Liu Yingbin
- Chu Peiguo
- Wang Linbo
- Yen Yun
DOIAbstract
We aimed to investigate the prognostic value of RRM1 in GC patients.A total of assessable 389 GC patients with clinicopathological and survival information were enrolled from City of Hope (COH, n = 67) and Zhejiang University (ZJU, n = 322). RRM1 protein expression was determined by immunohistochemistry on FFPE tissue samples. Kaplan-Meier and Cox analyses were used to measure survival. Ras/Raf activity and invasion assays were used to evaluate the role of RRM1 in GC cell lines.<0.01). In multivariate Cox analysis, the hazard ratios of RRM1 for overall survival were 2.55 (95% CI 1.27–5.15) and 1.51 (95% CI 1.07–2.13) in the COH and ZJU sets, respectively. In particular, RRM1 specifically predicted the outcome of advanced GCs with poor diffe...
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