Prostate epithelial cells depend on androgens for survival and function. In (early) prostate cancer (PCa) androgens also regulate tumor growth, which is exploited by hormonal therapies in metastatic disease. The aim of the present study was to characterize the androgen receptor (AR) response in hormonal therapy-resistant PC346 cells and identify potential disease markers.Human 19K oligoarrays were used to establish the androgen-regulated expression profile of androgen-responsive PC346C cells and its derivative therapy-resistant sublines: PC346DCC (vestigial AR levels), PC346Flu1 (AR overexpression) and PC346Flu2 (T877A AR mutation). In total, 107 transcripts were differentially-expressed in PC346C and derivatives after R1881 or hydroxyfluta...
Appraising the crucial role of androgen receptor (AR) in prostate cancer (PCa) initiation and progre...
Prostate cancer is initially dependent on androgens for survival and growth, making hormonal therapy...
Prostate cancer (PC) remains a leading cause of cancer-related deaths among men worldwide, despite c...
BACKGROUND: Prostate epithelial cells depend on androgens for survival and function. In (early) pros...
Background: Prostate epithelial cells depend on androgens for survival and function. In (early) pros...
textabstractBackground: Prostate epithelial cells depend on androgens for survival and function. In ...
Prostate cancer is initially dependent on androgens for survival and growth, making hormonal therapy...
Background: Prostate cancer is initially dependent on androgens for survival and growth, making horm...
Abstract Background The androgen receptor (AR) plays critical roles in both androgen-dependent and c...
Since the growth of prostate cancer is androgen-sensitive, metastatic disease has been treated by ho...
SummaryThe androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the ...
The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the commone...
Androgen receptor (AR) signaling remains the key therapeutic target in the management of hormone-nai...
Prostate cancer is initially dependent on androgens for survival and growth, making hormonal therapy...
Appraising the crucial role of androgen receptor (AR) in prostate cancer (PCa) initiation and progre...
Appraising the crucial role of androgen receptor (AR) in prostate cancer (PCa) initiation and progre...
Prostate cancer is initially dependent on androgens for survival and growth, making hormonal therapy...
Prostate cancer (PC) remains a leading cause of cancer-related deaths among men worldwide, despite c...
BACKGROUND: Prostate epithelial cells depend on androgens for survival and function. In (early) pros...
Background: Prostate epithelial cells depend on androgens for survival and function. In (early) pros...
textabstractBackground: Prostate epithelial cells depend on androgens for survival and function. In ...
Prostate cancer is initially dependent on androgens for survival and growth, making hormonal therapy...
Background: Prostate cancer is initially dependent on androgens for survival and growth, making horm...
Abstract Background The androgen receptor (AR) plays critical roles in both androgen-dependent and c...
Since the growth of prostate cancer is androgen-sensitive, metastatic disease has been treated by ho...
SummaryThe androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the ...
The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the commone...
Androgen receptor (AR) signaling remains the key therapeutic target in the management of hormone-nai...
Prostate cancer is initially dependent on androgens for survival and growth, making hormonal therapy...
Appraising the crucial role of androgen receptor (AR) in prostate cancer (PCa) initiation and progre...
Appraising the crucial role of androgen receptor (AR) in prostate cancer (PCa) initiation and progre...
Prostate cancer is initially dependent on androgens for survival and growth, making hormonal therapy...
Prostate cancer (PC) remains a leading cause of cancer-related deaths among men worldwide, despite c...