Insulin resistance in obstructive sleep apnea

AbstractIntroductionOSA is a common condition that is characterized by intermittent and recurrent pauses in respiration results in multiple cycles of hypoxia/reoxygenation with an increased production of reactive oxygen species (ROS).Aim of workIs to assess serum insulin level and insulin resistance in obese patients with and without OSA.Subjects and methodsStudy was performed on 51 obese subjects who had been referred to the Chest Department of Kasr Alaini Hospital with clinical suspicion of OSA in order to perform polysomnography. They were classified into two groups; cases: consist of 33 obese patients who were diagnosed as obstructive sleep apnea (OSA) and controls: consist of 18 obese subjects, without OSA as a control group. The two groups were subjected to polysomnographic study, serum insulin by ELISA and assessment of insulin resistance by calculation of HOMA index.ResultsThere was statistically highly significant increase in Epworth sleepiness scale (ESS) among cases compared to controls. As regards the polysomnographic data, there was statistically highly significant increase in AHI, desaturation index and duration of desaturation