Cost-Effectiveness of Coronary Artery Calcium Testing for Coronary Heart and Cardiovascular Disease Risk Prediction to Guide Statin Allocation: The Multi-Ethnic Study of Atherosclerosis (MESA)
- Roberts Eric T.
- Horne Aaron
- Martin Seth S.
- Blaha Michael J.
- Blankstein Ron
- Budoff Matthew J.
- Sibley Christopher
- Polak Joseph F.
- Frick Kevin D.
- Blumenthal Roger S.
- Nasir Khurram
DOIAbstract
The Multi-Ethnic Study of Atherosclerosis (MESA) showed that the addition of coronary artery calcium (CAC) to traditional risk factors improves risk classification, particularly in intermediate risk asymptomatic patients with LDL cholesterol levels <160 mg/dL. However, the cost-effectiveness of incorporating CAC into treatment decision rules has yet to be clearly delineated.To model the cost-effectiveness of CAC for cardiovascular risk stratification in asymptomatic, intermediate risk patients not taking a statin. Treatment based on CAC was compared to (1) treatment of all intermediate-risk patients, and (2) treatment on the basis of United States guidelines.We developed a Markov model of first coronary heart disease (CHD) and cardiovascula...
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