Correlation of Lung Collapse and Gas Exchange - A Computer Tomographic Study in Sheep and Pigs with Atelectasis in Otherwise Normal Lungs
- Wolf Samuel J.
- Reske Alexander P.
- Hammermüller Sören
- Costa Eduardo L. V.
- Spieth Peter M.
- Hepp Pierre
- Carvalho Alysson R.
- Kraßler Jens
- Wrigge Hermann
- Amato Marcelo B. P.
- Reske Andreas W.
DOIAbstract
) and intrapulmonary shunt have both been suggested to correlate with atelectasis, studies yielded inconsistent results. Therefore, we investigated these correlations.) to linearize its relationships with shunt and atelectasis. Data are given as median (interquartile range). and shunt. and shunt, when blood gases are measured during ventilation with pure oxygen. In lung-healthy pigs, these correlations were significantly weaker, likely because pigs have stronger hypoxic pulmonary vasoconstriction (HPV) than sheep and humans. Nevertheless, correlations improved also in pigs after blunting of HPV during ARDS. In humans, the observed relationships may aid in assessing anaesthesia-related atelectasis
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