Comprehensive behavioral analyses of transgenic and knockout mice have successfully identified the functional roles of many genes in the brain. Over the past 10 years, strategies for mouse behavioral phenotyping have evolved to maximize the scope and replicability of findings from a cohort of mutant mice, minimize the interpretation of procedural artifacts, and provide robust translational tools to test hypotheses and develop treatments. This Primer addresses experimental design issues and offers examples of high-throughput batteries, learning and memory tasks, and anxiety-related tests
More than a hundred de novo single gene mutations and copy-number variants have been implicated in a...
Behavioral neuroscience research incorporates the identical high level of meticulous methodologies a...
Chemical mutagenesis represents an efficient phenotype-driven approach to deriving new mutations for...
Comprehensive behavioral analyses of transgenic and knockout mice have successfully identified the f...
Animal models offer heuristic research tools to understand the causes of human diseases and to ident...
Genetically engineered strains of mice, modified by transgenesis or gene targeting ( knockouts ) are...
We report on a battery of behavioral screening tests that successfully identified several neurobehav...
We report on a battery of behavioral screening tests that successfully identified several neurobehav...
Behavioural analysis of mice carrying engineered mutations is widely used to identify roles of speci...
Mice altered by transgenesis or gene targeting (\u27knockouts\u27) have increasingly been employed a...
The first generation of genetic mutations in mice, conventional transgenics and knockouts, have prov...
Eighty percent of mammalian genes are expressed at detectable levels in the brain, and it has become...
Here, we describe the systematic mouse phenotyping approach of the German Mouse Clinic (GMC), that w...
This chapter describes a use case for the genetic dissection and automated analysis of complex behav...
A list of transgenic and knockout mice, having behavioral profiles, has been compiled. Behavioral an...
More than a hundred de novo single gene mutations and copy-number variants have been implicated in a...
Behavioral neuroscience research incorporates the identical high level of meticulous methodologies a...
Chemical mutagenesis represents an efficient phenotype-driven approach to deriving new mutations for...
Comprehensive behavioral analyses of transgenic and knockout mice have successfully identified the f...
Animal models offer heuristic research tools to understand the causes of human diseases and to ident...
Genetically engineered strains of mice, modified by transgenesis or gene targeting ( knockouts ) are...
We report on a battery of behavioral screening tests that successfully identified several neurobehav...
We report on a battery of behavioral screening tests that successfully identified several neurobehav...
Behavioural analysis of mice carrying engineered mutations is widely used to identify roles of speci...
Mice altered by transgenesis or gene targeting (\u27knockouts\u27) have increasingly been employed a...
The first generation of genetic mutations in mice, conventional transgenics and knockouts, have prov...
Eighty percent of mammalian genes are expressed at detectable levels in the brain, and it has become...
Here, we describe the systematic mouse phenotyping approach of the German Mouse Clinic (GMC), that w...
This chapter describes a use case for the genetic dissection and automated analysis of complex behav...
A list of transgenic and knockout mice, having behavioral profiles, has been compiled. Behavioral an...
More than a hundred de novo single gene mutations and copy-number variants have been implicated in a...
Behavioral neuroscience research incorporates the identical high level of meticulous methodologies a...
Chemical mutagenesis represents an efficient phenotype-driven approach to deriving new mutations for...