are as yet not entirely understood. However, there is evidence showing the involvement of host cell cytoskeleton in every step of establishment and persistence of mycobacterial infection.Here we show that expression of ARPC4, a subunit of the Actin related protein 2/3 (Arp2/3) protein complex, severely affects the pathogen’s growth. TEM studies display shedding of the mycobacterial outer-coat. Furthermore, in infected macrophages, mycobacteria expressing ARPC4 were cleared off at a much faster rate, and were unable to mount a pro-inflammatory cytokine response. The translocation of ARPC4-expressing mycobacteria to the lysosome of the infected macrophage was also impaired. Additionally, the ARPC4 subunit was shown to interact with Rv1626, a...
Intracellular pathogens have developed elaborate mechanisms to exploit the different cellular system...
The PE/PPE family of proteins which are in high abundance in pathogenic species such as Mycobacteriu...
Pathogenic mycobacteria reside in macrophages where they avoid lysosomal targeting and degradation t...
BACKGROUND: The search for molecules against Mycobacterium tuberculosis is urgent. The mechanisms fa...
Background: The search for molecules against Mycobacterium tuberculosis is urgent. The mechanisms fa...
International audienceThe interaction of Mycobacterium tuberculosis (Mtb) with pulmonary epithelial ...
Many key insights into actin regulation have been derived through examining how microbial pathogens ...
Tuberculosis, caused by Mycobacterium tuberculosis, remains the number one killer in the world toda...
The success of M. tuberculosis lies in its ability to stay alive and persist in a potentially hostil...
Mycobacterium tuberculosis (Mtb) can evade antimicrobial immunity and persist within macrophages by ...
Tuberculosis remains a major cause of morbidity and mortality worldwide as a result of Mycobacterium...
BACKGROUND: Microorganisms capable of surviving within macrophages are rare, but represent very succ...
Mycobacterium tuberculosis (Mtb) has evolved multiple strategies to counter the human immune system....
Mycobacteria are responsible for a number of human and animal diseases and are classical intracellul...
Pathogenic mycobacteria reside in macrophages where they avoid lysosomal targeting and degradation t...
Intracellular pathogens have developed elaborate mechanisms to exploit the different cellular system...
The PE/PPE family of proteins which are in high abundance in pathogenic species such as Mycobacteriu...
Pathogenic mycobacteria reside in macrophages where they avoid lysosomal targeting and degradation t...
BACKGROUND: The search for molecules against Mycobacterium tuberculosis is urgent. The mechanisms fa...
Background: The search for molecules against Mycobacterium tuberculosis is urgent. The mechanisms fa...
International audienceThe interaction of Mycobacterium tuberculosis (Mtb) with pulmonary epithelial ...
Many key insights into actin regulation have been derived through examining how microbial pathogens ...
Tuberculosis, caused by Mycobacterium tuberculosis, remains the number one killer in the world toda...
The success of M. tuberculosis lies in its ability to stay alive and persist in a potentially hostil...
Mycobacterium tuberculosis (Mtb) can evade antimicrobial immunity and persist within macrophages by ...
Tuberculosis remains a major cause of morbidity and mortality worldwide as a result of Mycobacterium...
BACKGROUND: Microorganisms capable of surviving within macrophages are rare, but represent very succ...
Mycobacterium tuberculosis (Mtb) has evolved multiple strategies to counter the human immune system....
Mycobacteria are responsible for a number of human and animal diseases and are classical intracellul...
Pathogenic mycobacteria reside in macrophages where they avoid lysosomal targeting and degradation t...
Intracellular pathogens have developed elaborate mechanisms to exploit the different cellular system...
The PE/PPE family of proteins which are in high abundance in pathogenic species such as Mycobacteriu...
Pathogenic mycobacteria reside in macrophages where they avoid lysosomal targeting and degradation t...