Variants Associated with Secretory Phospholipase A2-IIA Levels
- Exeter Holly J.
- Folkersen Lasse
- Palmen Jutta
- Franco-Cereceda Anders
- Cooper Jackie A.
- Kalea Anastasia Z.
- Hooft Ferdinand van’t
- Eriksson Per
- Humphries Steve E.
- Talmud Philippa J.
DOIAbstract
non-coding SNPs, rs11573156 C>G and rs3767221 T>G where the rare alleles have been previously associated with higher and lower sPLA2-IIA levels respectively.), suggesting rs11573156 G allele-specific exon 2 skipping.Both SNPs are functional and provide useful tools for Mendelian Randomisation to determine whether the relationship between sPLA2-IIA and coronary heart disease is causal
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