Cytokine Response Patterns in Severe Pandemic 2009 H1N1 and Seasonal Influenza among Hospitalized Adults
- Lee Nelson
- Wong Chun Kwok
- Chan Paul K. S.
- Chan Martin C. W.
- Wong Rity Y. K.
- Lun Samantha W. M.
- Ngai Karry L. K.
- Lui Grace C. Y.
- Wong Bonnie C. K.
- Lee Sharon K. W.
- Choi Kin Wing
- Hui David S. C.
DOIAbstract
Studying cytokine/chemokine responses in severe influenza infections caused by different virus subtypes may improve understanding on pathogenesis. culture (Whole Blood Assay,±PHA/LPS stimulation). Clinical variables were prospectively recorded and analyzed. (e.g. IL-6, CXCL8/IL-8, CCL2/MCP-1, CXCL10/IP-10, CXCL9/MIG); their ‘responsiveness’ to stimuli was shown to change dynamically during the illness course.A hyperactivated proinflammatory, but suppressed adaptive-immunity (Th1/Th17)-related cytokine response pattern was found in severe pH1N1 pneumonia, different from seasonal influenza. Cytokine/immune-dysregulation may be important in its pathogenesis
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