Results in Impaired Viability of the Parasite

were confirmed at the first time by silencing the gene function with RNA interference technique. siRNA1743 resulted in 37.6% decrease in adult worm burden and 23.2% decrease in muscle larvae burden compared with mice infected with control siRNA-treated larvae. In addition, adult worms recovered from mice infected with siRNA-treated larvae released 24.8% less newborn larvae. and therefore is a promising target for vaccine development