Haemophilus influenzae serotype b conjugate vaccine failure in twelve countries with established national childhood immunization programmes
- Ladhani, S.
- Slack, M.P.E.
- Ramsay, M.E.
- Heath, P.T.
- McIntyre, P.B.
- Diez-Domingo, J.
- Campos, J.
- Dagan, R.
- participants of the European Union Invasive Bacterial Infections Surveillance (EU-IBIS) Network,
DOIAbstract
AbstractThe present study describes the clinical and immunological features of children with Hib vaccine failure, who were identified through national surveillance between 1996 and 2001 in Europe, Israel and Australia. True vaccine failure was defined as invasive Hib disease occurring ≥2 weeks after one dose, given after the first birthday, or ≥1 week after ≥2 doses, given at <1 year of age. Of the 423 cases (representing 0.2 cases per 100 000 child-years at risk) reported, 330 (78%) had received three doses in the first year of life and developed disease at a median age of 28 months. Of the remaining 93, 48 had received two doses in infancy, 34 had received four doses including a booster, and 11 had received a single dose after 12 months o...
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