Natural History of Malignant Bone Disease in Hepatocellular Carcinoma: Final Results of a Multicenter Bone Metastasis Survey
- Santini Daniele
- Pantano Francesco
- Riccardi Ferdinando
- Di Costanzo Giovan Giuseppe
- Addeo Raffaele
- Guida Francesco Maria
- Ceruso Mariella Spalato
- Barni Sandro
- Bertocchi Paola
- Marinelli Sara
- Marchetti Paolo
- Russo Antonio
- Scartozzi Mario
- Faloppi Luca
- Santoni Matteo
- Cascinu Stefano
- Maiello Evaristo
- Silvestris Franco
- Tucci Marco
- Ibrahim Toni
- Masi Gianluca
- Gnoni Antonio
- Comandone Alessandro
- Fazio Nicola
- Conti Alessandro
- Imarisio Ilaria
- Pisconti Salvatore
- Giommoni Elisa
- Cinieri Saverio
- Catalano Vincenzo
- Palmieri Vincenzo Ostilio
- Infante Giovanni
- Aieta Michele
- Trogu Antonio
- Gadaleta Cosmo Damiano
- Brunetti Anna Elisabetta
- Lorusso Vito
- Silvestris Nicola
DOIAbstract
Bone is an uncommon site of metastasis in patients with advanced hepatocellular carcinoma (HCC). Therefore, there are few studies concerning the natural history of bone metastasis in patients with HCC.Data on clinicopathology, survival, skeletal-related events (SREs), and bone-directed therapies for 211 deceased HCC patients with evidence of bone metastasis were statistically analyzed. = 0.001).This study provides a significant improvement in the understanding the natural history of skeletal disease in HCC patients. An early and appropriate management of these patients is dramatically needed in order to avoid subsequent worsening of their quality of life
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