AbstractObjectives. This study was designed to compare the preventive effect of nitrate tolerance between carvedilol with antioxidant properties and arotinolol without antioxidant properties.Background. The attenuation of cyclic guanosine monophosphate (cGMP) production due to inactivation of guanylate cyclase by increased superoxide has been reported as a mechanism of nitrate tolerance. Carvedilol has been known to combine alpha- and beta-blockade with antioxidant properties.Methods. To evaluate the preventive effect of nitrate tolerance, 24 patients with untreated hypertension were randomized to receive either carvedilol (10 mg twice a day [carvedilol group, n = 8]), arotinolol (10 mg twice a day [arotinolol group, n = 8]), or placebo (pl...
AbstractOrganic nitrates, cornerstones of antianginal therapy, are believed to exert their principal...
AbstractObjectivesThis study was designed to assess the effect of oral L-arginine on the development...
The protective effects of carvedilol, a new /3-adrenergic receptor blocker and vasodilating antihype...
AbstractObjectives. This study was designed to compare the preventive effect of nitrate tolerance be...
AbstractObjectives. This study was designed to evaluate the effect of carvedilol on nitrate toleranc...
Background. Activation of neurohumoral hormones or sulflhydryl group depletion may contribute to the...
The definitive version is available at www.blackwell-synergy.comAims - Organic nitrates, via nitric ...
AbstractObjectives. This study sought to evaluate the preventive effect of vitamin C, an antioxidant...
Nitroglycerin (GTN) and other organic nitrates are widely used to treat patients with various cardio...
Background—The purpose of this study was to test whether carvedilol has an antioxidant effect in hum...
Objectives.This study was designed to determine the effect of oral hydralazine on the development of...
Background—The basis for progressive attenuation of the effects of organic nitrates during long-term...
The primary functions of the cardiovascular system are to transport the required nutrients to sustai...
Organic nitrates, such as nitroglycerin, are commonly used in the therapy of cardiovascular disease....
Chronic use of glyceryl trinitrate (GTN) is limited by serious side effects, such as tolerance and e...
AbstractOrganic nitrates, cornerstones of antianginal therapy, are believed to exert their principal...
AbstractObjectivesThis study was designed to assess the effect of oral L-arginine on the development...
The protective effects of carvedilol, a new /3-adrenergic receptor blocker and vasodilating antihype...
AbstractObjectives. This study was designed to compare the preventive effect of nitrate tolerance be...
AbstractObjectives. This study was designed to evaluate the effect of carvedilol on nitrate toleranc...
Background. Activation of neurohumoral hormones or sulflhydryl group depletion may contribute to the...
The definitive version is available at www.blackwell-synergy.comAims - Organic nitrates, via nitric ...
AbstractObjectives. This study sought to evaluate the preventive effect of vitamin C, an antioxidant...
Nitroglycerin (GTN) and other organic nitrates are widely used to treat patients with various cardio...
Background—The purpose of this study was to test whether carvedilol has an antioxidant effect in hum...
Objectives.This study was designed to determine the effect of oral hydralazine on the development of...
Background—The basis for progressive attenuation of the effects of organic nitrates during long-term...
The primary functions of the cardiovascular system are to transport the required nutrients to sustai...
Organic nitrates, such as nitroglycerin, are commonly used in the therapy of cardiovascular disease....
Chronic use of glyceryl trinitrate (GTN) is limited by serious side effects, such as tolerance and e...
AbstractOrganic nitrates, cornerstones of antianginal therapy, are believed to exert their principal...
AbstractObjectivesThis study was designed to assess the effect of oral L-arginine on the development...
The protective effects of carvedilol, a new /3-adrenergic receptor blocker and vasodilating antihype...