The Causal Effect of Vitamin D Binding Protein (DBP) Levels on Calcemic and Cardiometabolic Diseases: A Mendelian Randomization Study
- Leong Aaron
- Rehman Waheed
- Dastani Zari
- Greenwood Celia
- Timpson Nicholas
- Langsetmo Lisa
- Berger Claudie
- Fu Lei
- Wong Betty Y. L.
- Malik Suneil
- Malik Rainer
- Hanley David A.
- Cole David E. C.
- Goltzman David
- Richards J. Brent
DOIAbstract
Observational studies have shown that vitamin D binding protein (DBP) levels, a key determinant of 25-hydroxy-vitamin D (25OHD) levels, and 25OHD levels themselves both associate with risk of disease. If 25OHD levels have a causal influence on disease, and DBP lies in this causal pathway, then DBP levels should likewise be causally associated with disease. We undertook a Mendelian randomization study to determine whether DBP levels have causal effects on common calcemic and cardiometabolic disease. = 9,580/53,810).Please see later in the article for the Editors' Summar
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