Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure
- Baker Luisa A.
- Lee Karla C. L.
- Palacios Jimenez Carolina
- Alibhai Hatim
- Chang Yu-Mei
- Leckie Pamela J.
- Mookerjee Rajeshwar P.
- Davies Nathan A.
- Andreola Fausto
- Jalan Rajiv
DOIAbstract
MicroRNAs were released passively into the circulation in response to acetaminophen-induced cellular damage. A significant increase in global microRNA was detectable prior to significant increases in miR122, miR192 and miR124-1, which were associated with clinical evidence of liver, kidney and brain injury respectively
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