Alternative Complement Pathway Deregulation Is Correlated with Dengue Severity
- Nascimento Eduardo J. M.
- Silva Ana M.
- Cordeiro Marli T.
- Brito Carlos A.
- Gil Laura H. V. G.
- Braga-Neto Ulisses
- Marques Ernesto T. A.
DOIAbstract
The complement system, a key component that links the innate and adaptive immune responses, has three pathways: the classical, lectin, and alternative pathways. In the present study, we have analyzed the levels of various complement components in blood samples from dengue fever (DF) and dengue hemorrhagic fever (DHF) patients and found that the level of complement activation is associated with disease severity.<0.0001).The data suggest that an imbalance in the levels of regulatory factors D and H is associated with an abnormal regulation of complement activity in DHF patients
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