AbstractBackgroundPatients with critical limb ischaemia (CLI) unsuitable for revascularisation have a high rate of amputation and mortality (30% and 25% at 1 year, respectively). Localised gene therapy using plasmid DNA encoding acidic fibroblast growth factor (NV1FGF, riferminogene pecaplasmid) has showed an increased amputation-free survival in a phase II trial. This article provides the rationale, design and baseline characteristics of CLI patients enrolled in the pivotal phase III trial (EFC6145/TAMARIS).MethodsAn international, double-blind, placebo-controlled, randomised study composed of 525 CLI patients recruited from 170 sites worldwide who were unsuitable for revascularisation and had non-healing skin lesions was carried out to ev...
Recent data suggest that chronic critical limb ischaemia (CLI) is the most important reason for ampu...
Background: The impact of diabetes mellitus on the technical and clinical outcomes of infrainguinal ...
Background and Aims: Diabetes mellitus associates with poor outcomes in chronic limb threatening isc...
Background: Patients with critical limb ischaemia (CLI) unsuitable for revascularisation have a high...
AbstractBackgroundPatients with critical limb ischaemia (CLI) unsuitable for revascularisation have ...
BackgroundPatients with critical limb ischemia (CLI) unsuitable for revascularization have a high ra...
Vascular reconstruction remains a treatment of choice for critical limb ischemia. Bypass surgery has...
OBJECTIVE: Although never assessed prospectively, diabetes mellitus (DM) is assumed to negatively af...
AbstractObjectiveTo compare current revascularisation practice and outcome in diabetic and non-diabe...
Background Patients with critical limb ischaemia have a high rate of amputation and mortality. We te...
Background: During the 21st century, diabetes mellitus (DM) and peripheral artery disease (PAD) have...
BACKGROUND: Patients with diabetes concomitant to critical limb ischemia (CLI) represent a sub-group...
ObjectiveThe optimal revascularization strategy in diabetic patients with chronic critical limb isch...
Objective. To evaluate the early and late major amputation and survival rates and related risk facto...
The risk of major amputation is higher after urgently planned endovascular therapy for chronic limb-...
Recent data suggest that chronic critical limb ischaemia (CLI) is the most important reason for ampu...
Background: The impact of diabetes mellitus on the technical and clinical outcomes of infrainguinal ...
Background and Aims: Diabetes mellitus associates with poor outcomes in chronic limb threatening isc...
Background: Patients with critical limb ischaemia (CLI) unsuitable for revascularisation have a high...
AbstractBackgroundPatients with critical limb ischaemia (CLI) unsuitable for revascularisation have ...
BackgroundPatients with critical limb ischemia (CLI) unsuitable for revascularization have a high ra...
Vascular reconstruction remains a treatment of choice for critical limb ischemia. Bypass surgery has...
OBJECTIVE: Although never assessed prospectively, diabetes mellitus (DM) is assumed to negatively af...
AbstractObjectiveTo compare current revascularisation practice and outcome in diabetic and non-diabe...
Background Patients with critical limb ischaemia have a high rate of amputation and mortality. We te...
Background: During the 21st century, diabetes mellitus (DM) and peripheral artery disease (PAD) have...
BACKGROUND: Patients with diabetes concomitant to critical limb ischemia (CLI) represent a sub-group...
ObjectiveThe optimal revascularization strategy in diabetic patients with chronic critical limb isch...
Objective. To evaluate the early and late major amputation and survival rates and related risk facto...
The risk of major amputation is higher after urgently planned endovascular therapy for chronic limb-...
Recent data suggest that chronic critical limb ischaemia (CLI) is the most important reason for ampu...
Background: The impact of diabetes mellitus on the technical and clinical outcomes of infrainguinal ...
Background and Aims: Diabetes mellitus associates with poor outcomes in chronic limb threatening isc...