AbstractThe appropriate folding of catalytic RNA is a prerequisite for effective catalysis. A novel ribozyme, the maxizyme, has been generated and its activity can be controlled allosterically. The maxizymes work both in vitro and in vivo indicating the potential utility of this novel class of ribozyme as a gene-inactivating agent with a biosensor function
A series of allosteric ribozymes that respond to the bacterial second messenger cyclic diguanosyl-5′...
AbstractA population of catalytic RNA molecules has been engineered to operate and evolve in vitro i...
Hammerhead ribozymes are efficient RNA enzymes characterized by a typical hammerhead secondary struc...
AbstractBackground: Efficient operation of cellular processes relies on the strict control that each...
textRNA is ubiquitous in biology, and can interact with other biomolecules based on their primary, s...
Through evolution, enzymes have developed subtle modes of activation in order to ensure the sufficie...
Enzymes and ribozymes constitute two biological catalysts. The activity of many natural enzymes is r...
The discovery of catalytic RNA (ribozymes) more than 30 years ago significantly widened the horizon ...
Allosteric mechanisms are widely used in nature to control the rates of enzymatic reactions, but lit...
Ribozymes are widespread, and catalyze some extremely important reactions in the cell. Mechanistical...
The discovery that RNA can act as a biological catalyst, as well as a genetic molecule, indicated th...
The diverse functions of RNA provide numerous opportunities for programming biological circuits. We ...
Ribozymes,RNA molecules that catalyze the cleavage of RNA substrates, provide an interesting alterna...
Catalytic RNAs, known as ribozymes, act as true enzymes and are implicated in important biological p...
AbstractWe demonstrated previously that shortened forms of (stem II-deleted) hammerhead ribozymes wi...
A series of allosteric ribozymes that respond to the bacterial second messenger cyclic diguanosyl-5′...
AbstractA population of catalytic RNA molecules has been engineered to operate and evolve in vitro i...
Hammerhead ribozymes are efficient RNA enzymes characterized by a typical hammerhead secondary struc...
AbstractBackground: Efficient operation of cellular processes relies on the strict control that each...
textRNA is ubiquitous in biology, and can interact with other biomolecules based on their primary, s...
Through evolution, enzymes have developed subtle modes of activation in order to ensure the sufficie...
Enzymes and ribozymes constitute two biological catalysts. The activity of many natural enzymes is r...
The discovery of catalytic RNA (ribozymes) more than 30 years ago significantly widened the horizon ...
Allosteric mechanisms are widely used in nature to control the rates of enzymatic reactions, but lit...
Ribozymes are widespread, and catalyze some extremely important reactions in the cell. Mechanistical...
The discovery that RNA can act as a biological catalyst, as well as a genetic molecule, indicated th...
The diverse functions of RNA provide numerous opportunities for programming biological circuits. We ...
Ribozymes,RNA molecules that catalyze the cleavage of RNA substrates, provide an interesting alterna...
Catalytic RNAs, known as ribozymes, act as true enzymes and are implicated in important biological p...
AbstractWe demonstrated previously that shortened forms of (stem II-deleted) hammerhead ribozymes wi...
A series of allosteric ribozymes that respond to the bacterial second messenger cyclic diguanosyl-5′...
AbstractA population of catalytic RNA molecules has been engineered to operate and evolve in vitro i...
Hammerhead ribozymes are efficient RNA enzymes characterized by a typical hammerhead secondary struc...
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