Autonomic Regulation Therapy via Left or Right Cervical Vagus Nerve Stimulation in Patients With Chronic Heart Failure: Results of the ANTHEM-HF Trial
- Premchand, Rajendra K.
- Sharma, Kamal
- Mittal, Sanjay
- Monteiro, Rufino
- Dixit, Satyajit
- Libbus, Imad
- DiCarlo, Lorenzo A.
- Ardell, Jeffrey L.
- Rector, Thomas S.
- Amurthur, Badri
- KenKnight, Bruce H.
- Anand, Inder S.
DOIAbstract
AbstractObjectiveANTHEM-HF evaluated a novel autonomic regulation therapy (ART) via either left or right vagus nerve stimulation (VNS) in patients with heart failure (HF) and reduced ejection fraction (HFrEF).Methods and ResultsSixty subjects (New York Heart Association [NYHA] functional class II–III, left ventricular ejection fraction (LVEF) ≤40%, left ventricular end-diastolic diameter ≥50 mm to <80 mm) receiving optimal pharmacologic therapy were randomized at 10 sites. VNS systems were randomly implanted on the left (n = 31) or right (n = 29) side. All patients were successfully implanted and 59 were titrated over 10 weeks to a well tolerated stimulation intensity. One patient died 3 days after an embolic stroke that occurred during imp...
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