Functional effects of the antigen glatiramer acetate are complex and tightly associated with its composition
- Hasson, Tal
- Kolitz, Sarah
- Towfic, Fadi
- Laifenfeld, Daphna
- Bakshi, Shlomo
- Beriozkin, Olga
- Shacham-Abramson, Maya
- Timan, Bracha
- Fowler, Kevin D.
- Birnberg, Tal
- Konya, Attila
- Komlosh, Arthur
- Ladkani, David
- Hayden, Michael R.
- Zeskind, Benjamin
- Grossman, Iris
DOIAbstract
AbstractGlatiramer acetate (Copaxone®; GA) is a non-biological complex drug for multiple sclerosis. GA modulated thousands of genes in genome-wide expression studies conducted in THP-1 cells and mouse splenocytes. Comparing GA with differently-manufactured glatiramoid Polimunol (Synthon) in mice yielded hundreds of differentially expressed probesets, including biologically-relevant genes (e.g. Il18, adj p<9e−6) and pathways. In human monocytes, 700+ probesets differed between Polimunol and GA, enriching for 130+ pathways including response to lipopolysaccharide (adj. p<0.006). Key differences were confirmed by qRT-PCR (splenocytes) or proteomics (THP-1). These studies demonstrate the complexity of GA's mechanisms of action, and may help inf...
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