The gene for hepatocyte nuclear factor (HNF)-4α is activated by glucocorticoids and glucagon, and repressed by insulin in rat liver
- Oyadomari, Seiichi
- Matsuno, Fumihiko
- Chowdhury, Shoaib
- Kimura, Tatsuya
- Iwase, Katsuro
- Araki, Eiichi
- Shichiri, Motoaki
- Mori, Masataka
- Takiguchi, Masaki
Publication date
July 2000
DOI Publisher
Federation of European Biochemical Societies. Published by Elsevier B.V.Abstract
AbstractThe gene for a transcription factor hepatocyte nuclear factor-4α (HNF-4α) is responsible for maturity-onset diabetes of the young, type 1. We examined hormonal regulation of the HNF-4α gene in the liver. Stimulation of primary-cultured rat hepatocytes with dexamethasone or glucagon led to induction of HNF-4α mRNA, being antagonized by insulin. In the liver of streptozotocin-induced diabetic rat, mRNA and protein levels for HNF-4α were elevated, and were normalized by insulin treatment. Therefore, HNF-4α in the liver is likely to be involved in the regulation of glucose metabolism in response to these hormones
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