AbstractDithiocarbamates are nitrogen- and sulfur-containing compounds commonly used in pharmacology, medicine and agriculture. The molecular effects of dithiocarbamates on neuronal cell systems are not fully understood, especially in terms of their ability to accumulate copper ions inside the cell. In this work, the molecular effects of N,N-diethyldithiocarbamate (DEDTC) were studied in human SH-SY5Y neuroblastoma cells to determine the role of copper in the DEDTC toxicity and the pathway trigged in cell by the complex Cu-DEDTC. From concentration-dependent studies, we found that 5μM of this compound induced a drastic decrease in viable cells with a concomitant accumulation in intracellular copper resulted from complexation with DEDTC, mea...
Treatment of SH-SY5Y human neuroblastoma cells with copper sulphate (50-300microM) in complete mediu...
Transition metals are essential, but deregulation of their metabolism causes toxicity. Here, we repo...
Zinc and copper are trace elements essential for proper folding, stabilization and catalytic activit...
<p><b>(A)</b> Disulfiram is metabolized to diethyldithiocarbamate (DDC) and DDC complexes with Coppe...
Pyrrolidine dithiocarbamate (PDTC) is a metal chelator. Biologically, slight toxic affects EC(50,)10...
Astrocytes play a critical neurotrophic and neuroprotective role in the brain, and improper function...
The use of chelators for cancer treatment has been an alternative option. Dithiocarbamates have rece...
Copper homeostasis is generally investigated focusing on a single component of the metallostasis net...
Nuclear factor kappaB (NF-kappaB) is a transcription factor involved in the expression of a wide ran...
AbstractIt is a therapeutic strategy for cancers including pancreatic to inhibit proteasome activity...
The antioxidant and metal-chelating effects of pyrrolidine dithiocarbamate (PDTC) have been extensiv...
SH-SY5Y neuroblastoma cells were cultured for up to three serial passages in the presence of the cop...
The basic mechanism(s) by which altered Cu homeostasis is toxic to hepatocytes and neurons, the two ...
We report a quantitative structure−activity relationship study of a new class of pyrazole-pyridine c...
Diethyldithiocarbamate (ditiocarb), a metabolite of the old anti-alcoholic drug disulfiram (Antabuse...
Treatment of SH-SY5Y human neuroblastoma cells with copper sulphate (50-300microM) in complete mediu...
Transition metals are essential, but deregulation of their metabolism causes toxicity. Here, we repo...
Zinc and copper are trace elements essential for proper folding, stabilization and catalytic activit...
<p><b>(A)</b> Disulfiram is metabolized to diethyldithiocarbamate (DDC) and DDC complexes with Coppe...
Pyrrolidine dithiocarbamate (PDTC) is a metal chelator. Biologically, slight toxic affects EC(50,)10...
Astrocytes play a critical neurotrophic and neuroprotective role in the brain, and improper function...
The use of chelators for cancer treatment has been an alternative option. Dithiocarbamates have rece...
Copper homeostasis is generally investigated focusing on a single component of the metallostasis net...
Nuclear factor kappaB (NF-kappaB) is a transcription factor involved in the expression of a wide ran...
AbstractIt is a therapeutic strategy for cancers including pancreatic to inhibit proteasome activity...
The antioxidant and metal-chelating effects of pyrrolidine dithiocarbamate (PDTC) have been extensiv...
SH-SY5Y neuroblastoma cells were cultured for up to three serial passages in the presence of the cop...
The basic mechanism(s) by which altered Cu homeostasis is toxic to hepatocytes and neurons, the two ...
We report a quantitative structure−activity relationship study of a new class of pyrazole-pyridine c...
Diethyldithiocarbamate (ditiocarb), a metabolite of the old anti-alcoholic drug disulfiram (Antabuse...
Treatment of SH-SY5Y human neuroblastoma cells with copper sulphate (50-300microM) in complete mediu...
Transition metals are essential, but deregulation of their metabolism causes toxicity. Here, we repo...
Zinc and copper are trace elements essential for proper folding, stabilization and catalytic activit...