Action of Valeriana jatamansi Jones on the Apoptosis-related Genes Expression in the Anxiety Model of Rat

AbstractAimsTo observe the apoptosis-related genes expression in the difference groups and the action of Valeriana jatamansi Jones.MethodsEPM was used to make the anxiety model of rat. The gene expression difference chart of apoptosis-related gene in normal rats, anxiety model rats and rats treated by the extract of Valeriana jatamansi Jones were examined by using the gene chip technology.ResultsCompared with normal group, the expression of Elk-1, Ets-1, Apaf-1, Bax and Bcl-2 were up-regulated in the model group. But the abnormal gene expression were adjusted in the other groups.ConclusionThe Valeriana jatamansi Jones can play a important role in regulating the abnormal apoptosis-related gene expression in the anxiety model of rat