The Effect of Methotrexate on Cell Division in the Epidermis of the Young Rat*
- Robinson, Trevor W.E.
- Stoughton, Richard B.
Publication date
September 1969
DOI Publisher
The Williams and Wilkins Co. Published by Elsevier Inc.Abstract
ABSTRACTMethotrexate produces significant mitotic depression in the interfollicular epidermis of the young rat in two hours. This effect persists up to and includes a 24 hour group.There is no evidence of metaphase arrest produced by this drug.Follicular mitotic activity is reduced as rapidly as the interfollicular basal cell counts. A quick screening test for establishing antimitotic effects on epidermis is described. The test is based on follicular mitotic activity
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