AbstractThe abnormal cytoskeletal organization observed in Alzheimer's disease has been suggested to arise from hyperphosphorylation of tau and the resultant elimination of its ability to associate with microtubules. This possibility has been supported by a number of studies under cell-free conditions utilizing various kinases, phosphatases and their corresponding inhibitors each, and by treatment of intact cells with kinase and phosphatase activators and inhibitors. However, in studies utilizing intact cells, it remained difficult to attribute microtubule compromise specifically to tau hyperphosphorylation due to potential influence of inhibitors on tubulin and/or other microtubule-associated proteins, which themselves possess assembly-reg...
AbstractThe microtubule-associated protein tau, abundant in neurons, has gained notoriety due to the...
Hyperphosphorylated tau proteins accumulate in the paired helical filaments of neurofibrillary tangl...
AbstractIn Alzheimer disease brain the microtubule associated protein (MAP) τ is abnormally hyperpho...
AbstractIn a normal mature neuron, microtubule associated protein tau promotes the assembly of tubul...
AbstractIn Alzheimer disease (AD) the microtubule associated protein (MAP) tau is hyperphosphorylate...
AbstractUnlike normal tau, abnormally hyperphosphorylated tau (AD P-tau) from Alzheimer disease (AD)...
In normal adult brain the microtubule associated protein tau contains 2–3 phosphates per mole of the...
AbstractIn Alzheimer disease (AD) the microtubule associated protein (MAP) tau is hyperphosphorylate...
Phosphorylated forms of microtubule-associated protein tau accumulate in neurofibrillary tangles in ...
Phosphorylated forms of microtubule-associated protein tau accumulate in neurofibrillary tangles in ...
Background: Early stages of Alzheimer's disease (AD) are characterized by high phosphorylation of mi...
Aberrant protein phosphorylation is a hallmark of neurodegenerative diseases, such as Alzheimer's di...
Microtubule-associated protein tau is the major component of paired helical filaments (PHFs) associa...
AbstractPhosphorylated forms of microtubule-associated protein tau accumulate in neurofibrillary tan...
<div><p>Microtubule-associated protein tau is the major component of paired helical filaments (PHFs)...
AbstractThe microtubule-associated protein tau, abundant in neurons, has gained notoriety due to the...
Hyperphosphorylated tau proteins accumulate in the paired helical filaments of neurofibrillary tangl...
AbstractIn Alzheimer disease brain the microtubule associated protein (MAP) τ is abnormally hyperpho...
AbstractIn a normal mature neuron, microtubule associated protein tau promotes the assembly of tubul...
AbstractIn Alzheimer disease (AD) the microtubule associated protein (MAP) tau is hyperphosphorylate...
AbstractUnlike normal tau, abnormally hyperphosphorylated tau (AD P-tau) from Alzheimer disease (AD)...
In normal adult brain the microtubule associated protein tau contains 2–3 phosphates per mole of the...
AbstractIn Alzheimer disease (AD) the microtubule associated protein (MAP) tau is hyperphosphorylate...
Phosphorylated forms of microtubule-associated protein tau accumulate in neurofibrillary tangles in ...
Phosphorylated forms of microtubule-associated protein tau accumulate in neurofibrillary tangles in ...
Background: Early stages of Alzheimer's disease (AD) are characterized by high phosphorylation of mi...
Aberrant protein phosphorylation is a hallmark of neurodegenerative diseases, such as Alzheimer's di...
Microtubule-associated protein tau is the major component of paired helical filaments (PHFs) associa...
AbstractPhosphorylated forms of microtubule-associated protein tau accumulate in neurofibrillary tan...
<div><p>Microtubule-associated protein tau is the major component of paired helical filaments (PHFs)...
AbstractThe microtubule-associated protein tau, abundant in neurons, has gained notoriety due to the...
Hyperphosphorylated tau proteins accumulate in the paired helical filaments of neurofibrillary tangl...
AbstractIn Alzheimer disease brain the microtubule associated protein (MAP) τ is abnormally hyperpho...