Adenoid cystic carcinoma arising the anterior lingual gland (Blandin–Nuhn gland)

AbstractThe present case describes a rare example of adenoid cystic carcinoma (ACC) arising the Blandin-Nuhn gland. A 75-year-old Japanese woman took a partial glossectomy, hemimandiblectomy, excision of the hypoglossal nerve and a skin grafting. The tumor tissue consisted of tubular type of ACC and perineural invasion. The tumor cells were immunoreactive for S-100, keratin, α-smooth muscle actin (α-SMA) and PCNA. Numbers of PCNA and α-SMA positive cells were higher in modified or perineural tumor cells than that in tubular tumor cells. Biological roles of ACC invasion might be related to exist of PCNA and actin