ObjectivesWe aimed to test whether attenuation of early-phase cardiac cell death can prevent diabetic cardiomyopathy.BackgroundOur previous study showed that cardiac apoptosis as a major early cellular response to diabetes is induced by hyperglycemia-derived oxidative stress that activates a mitochondrial cytochrome c-mediated caspase-3 activation pathway. Metallothionein (MT) as a potent antioxidant prevents the development of diabetic cardiomyopathy.MethodsDiabetes was induced by a single dose of streptozotocin (STZ) (150 mg/kg) in cardiac-specific, metallothionein-overexpressing transgenic (MT-TG) mice and wild-type (WT) controls. On days 7, 14, and 21 after STZ treatment, cardiac apoptosis was examined by terminal deoxynucleotidyl trans...
Aims/hypothesis An increase in the production of reactive oxygen species is commonly thought to cont...
Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular remodeling, p...
Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular remodeling, p...
ObjectivesWe aimed to test whether attenuation of early-phase cardiac cell death can prevent diabeti...
ObjectivesWe evaluated metallothionein (MT)-mediated cardioprotection from angiotensin II (Ang II)–i...
Many individuals with diabetes experience impaired cardiac contractility that cannot be explained by...
Many individuals with diabetes experience impaired cardiac contractility that cannot be explained by...
Metallothioneins (MTs) are a group of intracellular metal-binding and cysteine-enriched proteins and...
Diabetes is a growing problem in Canada. Cardiovascular disease (CVD) remains the major cause of mor...
Diabetic cardiomyopathy, a disorder of the heart muscle in diabetic patients, is one of the major ca...
protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3b and mitochondrial fun...
Diabetes is one of the fastest growing chronic diseases of the 21st century. Diabetic patients are a...
Diabetic cardiomyopathy, the changes to myocardial structure and function directly attributed to dia...
Diabetic cardiomyopathy, a disorder of the heart muscle in diabetic patients, is one of the major ca...
High glucose-induced oxidative stress is a major contributing mechanism to the development of diabet...
Aims/hypothesis An increase in the production of reactive oxygen species is commonly thought to cont...
Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular remodeling, p...
Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular remodeling, p...
ObjectivesWe aimed to test whether attenuation of early-phase cardiac cell death can prevent diabeti...
ObjectivesWe evaluated metallothionein (MT)-mediated cardioprotection from angiotensin II (Ang II)–i...
Many individuals with diabetes experience impaired cardiac contractility that cannot be explained by...
Many individuals with diabetes experience impaired cardiac contractility that cannot be explained by...
Metallothioneins (MTs) are a group of intracellular metal-binding and cysteine-enriched proteins and...
Diabetes is a growing problem in Canada. Cardiovascular disease (CVD) remains the major cause of mor...
Diabetic cardiomyopathy, a disorder of the heart muscle in diabetic patients, is one of the major ca...
protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3b and mitochondrial fun...
Diabetes is one of the fastest growing chronic diseases of the 21st century. Diabetic patients are a...
Diabetic cardiomyopathy, the changes to myocardial structure and function directly attributed to dia...
Diabetic cardiomyopathy, a disorder of the heart muscle in diabetic patients, is one of the major ca...
High glucose-induced oxidative stress is a major contributing mechanism to the development of diabet...
Aims/hypothesis An increase in the production of reactive oxygen species is commonly thought to cont...
Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular remodeling, p...
Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular remodeling, p...