AbstractChk1 kinase, a DNA damage/replication G2 checkpoint kinase, has recently been shown to phosphorylate and inhibit Cdc25C, a Cdc2 Tyr-15 phosphatase, thereby directly linking the G2 checkpoint to negative regulation of Cdc2. Immature Xenopus oocytes are arrested naturally at the first meiotic prophase (prophase I) or the late G2 phase, with sustained Cdc2 Tyr-15 phosphorylation. Here we have cloned a Xenopus homolog of Chk1, determined its developmental expression, and examined its possible role in prophase I arrest of oocytes. Xenopus Chk1 protein is expressed at approximately constant levels throughout oocyte maturation and early embryogenesis. Overexpression of wild-type Chk1 in oocytes prevents the release from prophase I arrest b...
The early cell divisions of many metazoan embryos are rapid and occur in the near absence of transcr...
<p>Checkpoint 1 (Chk1), as an important member of DNA replication checkpoint and DNA damage response...
Early Xenopus laevis embryonic cell cycles exemplify rapid, non-pathological cell cycles without che...
AbstractChk1 kinase, a DNA damage/replication G2 checkpoint kinase, has recently been shown to phosp...
AbstractChk1, a nuclear DNA damage/replication G2 checkpoint kinase, phosphorylates Cdc25 and causes...
Activation of Cdc2/cyclin B kinase and entry into mitosis requires dephosphorylation of inhibitory s...
AbstractXenopus oocytes arrested in prophase I resume meiotic division in response to progesterone a...
As a tumor suppressor homologue during mitosis, Chk2 is involved in replication checkpoints, DNA rep...
G2/M phase transition in eukaryotic cell is driven by the maturation-promoting factor (MPF), which i...
The early cell divisions of many metazoan embryos are rapid and occur in the near absence of transcr...
International audienceXenopus oocytes are arrested in meiotic prophase I and resume meiotic division...
SummaryInduction of G2/M phase transition in mitotic and meiotic cell cycles requires activation by ...
AbstractATR and Chk1 are important components of a cell cycle checkpoint pathway. In this issue of D...
Fully grown Xenopus oocyte is arrested at prophase I of meiosis. Re-entry into meiosis depends on th...
AbstractIn mammalian cells the Cdc25 family of dual-specificity phosphatases has three distinct isof...
The early cell divisions of many metazoan embryos are rapid and occur in the near absence of transcr...
<p>Checkpoint 1 (Chk1), as an important member of DNA replication checkpoint and DNA damage response...
Early Xenopus laevis embryonic cell cycles exemplify rapid, non-pathological cell cycles without che...
AbstractChk1 kinase, a DNA damage/replication G2 checkpoint kinase, has recently been shown to phosp...
AbstractChk1, a nuclear DNA damage/replication G2 checkpoint kinase, phosphorylates Cdc25 and causes...
Activation of Cdc2/cyclin B kinase and entry into mitosis requires dephosphorylation of inhibitory s...
AbstractXenopus oocytes arrested in prophase I resume meiotic division in response to progesterone a...
As a tumor suppressor homologue during mitosis, Chk2 is involved in replication checkpoints, DNA rep...
G2/M phase transition in eukaryotic cell is driven by the maturation-promoting factor (MPF), which i...
The early cell divisions of many metazoan embryos are rapid and occur in the near absence of transcr...
International audienceXenopus oocytes are arrested in meiotic prophase I and resume meiotic division...
SummaryInduction of G2/M phase transition in mitotic and meiotic cell cycles requires activation by ...
AbstractATR and Chk1 are important components of a cell cycle checkpoint pathway. In this issue of D...
Fully grown Xenopus oocyte is arrested at prophase I of meiosis. Re-entry into meiosis depends on th...
AbstractIn mammalian cells the Cdc25 family of dual-specificity phosphatases has three distinct isof...
The early cell divisions of many metazoan embryos are rapid and occur in the near absence of transcr...
<p>Checkpoint 1 (Chk1), as an important member of DNA replication checkpoint and DNA damage response...
Early Xenopus laevis embryonic cell cycles exemplify rapid, non-pathological cell cycles without che...