AbstractMale mice deficient in BCLW, a death-protecting member of the BCL2 family, are sterile due to an arrest in spermatogenesis that is associated with a gradual loss of germ cells and Sertoli cells from the testis. As Bclw is expressed in both Sertoli cells and diploid male germ cells, it has been unclear which of these cell types requires BCLW in a cell-autonomous manner for survival. To determine whether death of Sertoli cells in Bclw mutants is influenced by the protracted loss of germ cells, we examined testes from Bclw/c-kit double mutant mice, which lack germ cells from birth. Loss of BCLW-deficient Sertoli cells occurs in the absence of germ cells, indicating that germ cell death is not required to mediate loss of Sertoli cells i...
In mammals, formation of the primordial follicle is a complex process involving the breakdown of ger...
Apoptosis is the main cause of primordial germ cell and oocyte degeneration in the developing fetal ...
Testicular apoptosis is involved in the regulation of germ cell numbers, allowing optimal sperm prod...
The BH3-only proteins of the Bcl-2 family initiate apoptosis through the activation of Bax-like rela...
AbstractIn germ cells, the function of which is to form the next generation, apoptotic cell death oc...
Apoptosis has a major role in molding the embryo, in the maintenance of tissue homeostasis, and in t...
Transgenic mice expressing high levels of the BclxL or Bcl2 proteins in the male germinal cells show...
Germ cell death is very common in mammalian testis, during both early testicular development and in ...
AbstractA homozygous nonsense mutation (Ter) in murine Dnd1 (Dnd1Ter/Ter) results in a significant e...
The pro-apoptotic BCL-2 family proteins BAX and BAK serve as essential gatekeepers of the intrinsic ...
The multi-BCL-2 homology domain pro-apoptotic BCL-2 family members BAK and BAX have critical roles i...
It has been proposed that Bcl-x is a key survival factor in many cell types, and that the bcl-x gene...
The proapoptotic members of the Bcl-2 family can be subdivided into members that contain several Bcl...
CBA/N mice carry an X-linked immunodeficiency (xid) due to a point mutation in the Bruton\u27s tyros...
AbstractCell death in the germ line is controlled by both positive and negative mechanisms that main...
In mammals, formation of the primordial follicle is a complex process involving the breakdown of ger...
Apoptosis is the main cause of primordial germ cell and oocyte degeneration in the developing fetal ...
Testicular apoptosis is involved in the regulation of germ cell numbers, allowing optimal sperm prod...
The BH3-only proteins of the Bcl-2 family initiate apoptosis through the activation of Bax-like rela...
AbstractIn germ cells, the function of which is to form the next generation, apoptotic cell death oc...
Apoptosis has a major role in molding the embryo, in the maintenance of tissue homeostasis, and in t...
Transgenic mice expressing high levels of the BclxL or Bcl2 proteins in the male germinal cells show...
Germ cell death is very common in mammalian testis, during both early testicular development and in ...
AbstractA homozygous nonsense mutation (Ter) in murine Dnd1 (Dnd1Ter/Ter) results in a significant e...
The pro-apoptotic BCL-2 family proteins BAX and BAK serve as essential gatekeepers of the intrinsic ...
The multi-BCL-2 homology domain pro-apoptotic BCL-2 family members BAK and BAX have critical roles i...
It has been proposed that Bcl-x is a key survival factor in many cell types, and that the bcl-x gene...
The proapoptotic members of the Bcl-2 family can be subdivided into members that contain several Bcl...
CBA/N mice carry an X-linked immunodeficiency (xid) due to a point mutation in the Bruton\u27s tyros...
AbstractCell death in the germ line is controlled by both positive and negative mechanisms that main...
In mammals, formation of the primordial follicle is a complex process involving the breakdown of ger...
Apoptosis is the main cause of primordial germ cell and oocyte degeneration in the developing fetal ...
Testicular apoptosis is involved in the regulation of germ cell numbers, allowing optimal sperm prod...